Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression

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Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression.

Accumulating studies support the idea that a common progenitor, termed the hemangioblast, generates both hematopoietic and endothelial cell lineages. To better define the relationship between these cell lineages, we have generated knock-in embryonic stem (ES) cells carrying a non-functional human CD4 at the Scl locus. By using in vitro differentiated Scl(+/CD4) ES cells, we demonstrate that FLK...

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ژورنال

عنوان ژورنال: Development

سال: 2002

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.00149